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  • Human ITK Recombinant protein (GST tag)

Human ITK Recombinant protein (GST tag)

Cat.#: 509148

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Product Information

  • Product Name
    Human ITK Recombinant protein (GST tag)
  • Documents
  • Description
    Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. {PubMed:12186560, PubMed:12682224, PubMed:21725281}.
  • Protein name
    Tyrosine-protein kinase ITK/TSK
  • Protein short names
    EMT; LYK
  • Uniprot ID
    Q08881
  • Gene Name
    ITK; EMT; LYK
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    151-258 aa encoded by BC109077 was inserted into PGEX-4T vector
  • Protein Species
    Human
  • Activity
    Not tested.
  • Validations

    Recombinant human ITK SDS-PAGE

    Recombinant human ITK SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"