NovoPro
Cart 2
  • Human IL36A/FIL1E/IL1E/IL1F6 recombinant protein

Human IL36A/FIL1E/IL1E/IL1F6 recombinant protein

Cat.#: 518630

Special Price 156.8 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Human IL36A/FIL1E/IL1E/IL1F6 recombinant protein
  • Documents
  • Description
    Human Interleukin-36α (IL-36α) is a secreted cytokine that belongs to the Interleukin 1 cytokine family. IL-36α is expressed in the immune system and the fetal brain, but not in other tissues or multiple hematopoietic cell lines. IL-36α is the only IL-1 family member found to be expressed on T-cells. IL-36α and IL-1F8 are involved in the regulation of adipose tissue gene expression. Importantly, IL-36α inhibits PPARγ expression, which may lead to a reduction in adipocyte differentiation suggesting metabolic effects of this cytokine. IL-36α, along with IL-1F8 and IL-1F9, has been shown to act as an agonist by activating the pathway involving NFκB and MAPK in an IL-1Rrp2 dependent manner. This suggest that IL-36α may signal in a similar fashion to IL-1 and IL-18 in having a binding receptor which upon ligation, recruits a second receptor as a signaling component, forming an active heterodimeric receptor complex.
  • Protein name
    interleukin 36, alpha(IL36A)
  • Protein short names
    FIL1E; IL1E; IL1F6
  • Uniprot ID
    Q9UHA7
  • Source/Expression Host
    E.coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Human IL36A/FIL1E/IL1E/IL1F6 Met1-Phe158 is expressed.
  • Protein Species
    Human
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Human IL36A/FIL1E/IL1E/IL1F6 recombinant protein

    Human IL36A/FIL1E/IL1E/IL1F6 recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"