Human IL-29 recombinant protein

Cat.#: 503908

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Product Information

  • Product Name
    Human IL-29 recombinant protein
  • Documents
  • Description
    Interleukin-29(IL-29), also known as cytokine Zcyto21, Interferon lambda-1, IFN-lambda-1, and IFNL1, is a secreted protein which belongs to the IL-28 / IL-29 family. IL-29 is a cytokine with immunomodulatory activity. IL-29 is highly similar in amino acid sequence to the IL-28. IL-28 and IL-29 are induced by viral infection and showed antiviral activity. IL-28 and IL-29 interacted with a heterodimeric class II cytokine receptor that consisted of IL-10 receptor beta (IL-10Rbeta) and an orphan class II receptor chain, designated IL-28Ralpha. IL-29 plays an important role in host defenses against microbes and its gene is highly upregulated in cells infected with viruses. IL-29 may play a role in antiviral immunity. IL-29 up-regulates MHC class I antigen expression. It is a Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand / receptor complex seems to signal through the Jak-STAT pathway.
  • Protein name
    Interferon lambda-1
  • Protein short names
    IL29; INTERFERON LAMBDA-1; IL-29; IFN-LAMBDA-1; IFNL1
  • Uniprot ID
    Q8IU54
  • Gene Name
    IFNL1; IL29; ZCYTO21
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human IFNL1 (NP_742152.1) (Met1-Thr200) was expressed with an initial Met.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human IFNL1 consists 182 amino acids and predicts a molecular mass of 20.2 kDa.
  • Purity
    > (80.7+15.8) % as determined by SDS-PAGE.
  • Activity
    Measured in antiviral assays using HepG2 cells infected with vesicular stomatitis virus.
    The ED50 for this effect is typically 10-39 ng/mL.
  • Validations

    Human IL29 / IFNL1 Protein SDS-PAGE

    Human IL29 / IFNL1 Protein SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"