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Product Name
Human IL-29 recombinant protein
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Description
Interleukin-29(IL-29), also known as cytokine Zcyto21, Interferon lambda-1, IFN-lambda-1, and IFNL1, is a secreted protein which belongs to the IL-28 / IL-29 family. IL-29 is a cytokine with immunomodulatory activity. IL-29 is highly similar in amino acid sequence to the IL-28. IL-28 and IL-29 are induced by viral infection and showed antiviral activity. IL-28 and IL-29 interacted with a heterodimeric class II cytokine receptor that consisted of IL-10 receptor beta (IL-10Rbeta) and an orphan class II receptor chain, designated IL-28Ralpha. IL-29 plays an important role in host defenses against microbes and its gene is highly upregulated in cells infected with viruses. IL-29 may play a role in antiviral immunity. IL-29 up-regulates MHC class I antigen expression. It is a Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand / receptor complex seems to signal through the Jak-STAT pathway.
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Protein name
Interferon lambda-1
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Protein short names
IL29; INTERFERON LAMBDA-1; IL-29; IFN-LAMBDA-1; IFNL1
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Uniprot ID
Q8IU54
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Gene Name
IFNL1; IL29; ZCYTO21
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human IFNL1 (NP_742152.1) (Met1-Thr200) was expressed with an initial Met.
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Protein Species
Human
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Molecular weight
The recombinant human IFNL1 consists 182 amino acids and predicts a molecular mass of 20.2 kDa.
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Purity
> (80.7+15.8) % as determined by SDS-PAGE.
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Activity
Measured in antiviral assays using HepG2 cells infected with vesicular stomatitis virus.
The ED50 for this effect is typically 10-39 ng/mL. -
Validations
Human IL29 / IFNL1 Protein SDS-PAGE
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