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Product Name
Human IFNAR1 (His Tag) recombinant protein
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Description
Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1, in which Tyr466 is changed to phenylalanine, can act in a dominant negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.
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Protein name
Interferon alpha/beta receptor 1
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Protein short names
INFAR; IFNAR; IFNBR; CRF2-1; IFN-ALPHA-REC; IFRC; IFNAR1; IFN-R-1; CD118; IFAR; AVP
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Uniprot ID
P17181
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Gene Name
IFNAR1; IFNAR
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human IFNAR1 isoform 1 (P17181-1) extracellular domain (Met 1-Lys 436) was fused with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human IFNAR1/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 420 amino acids and has a predicted molecular mass of 48.6 kDa. The apparent molecular mass of the reduced monomer is approximately 70-80 kDa in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
> 97 % as determined by SDS-PAGE
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Validations
Human IFNAR1 / IFNAR Protein (His Tag) SDS-PAGE
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