Human GRB2/ASH (His tag) recombinant protein

Cat.#: 518891

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Product Information

  • Product Name
    Human GRB2/ASH (His tag) recombinant protein
  • Documents
  • Description
    As an adaptor protein, Growth Factor Receptor-Bound Protein 2 (GRB2) is involved in siganl transduction and consists of a central SH2 domain flanked by two SH3 domains. GRB2 associates with activated Tyr-phosphorylated EGF receptor/EGFR and PDGF receptors via its SH2 domain, stimulating GTP binding to Ras, which in turn activates MAPK and other signaling pathway.It also associates to other cellular Tyr-phosphorylated proteins such as SIT1, IRS1, IRS4, SHC and LNK. probably via the concerted action of both its SH2 and SH3 domains.
  • Protein name
    growth factor receptor bound protein 2(GRB2)
  • Protein short names
    ASH
  • Uniprot ID
    P62993
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Human GRB2/ASH Met1-Val217 is expressed with a 6His tag at the C-terminus.
  • Protein Species
    Human
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Human GRB2/ASH (His tag) recombinant protein

    Human GRB2/ASH (His tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"