Human GLI1 Recombinant protein (GST tag)

Human GLI1 Recombinant protein (GST tag)

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Acts as a transcriptional activator (PubMed:19706761, PubMed:10806483, PubMed:19878745, PubMed:24311597, PubMed:24217340). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:8378770, PubMed:24217340). May regulate the transcription of specific genes during normal development (PubMed:19706761). May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761). Plays a role in cell proliferation and differentiation via its role in SHH signaling (Probable). {PubMed:10806483, PubMed:11238441, PubMed:19706761, PubMed:19878745, PubMed:2105456, PubMed:24217340, PubMed:24311597, PubMed:8378770, }.; Isoform 2: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration. {PubMed:19706761}.

Zinc finger protein GLI1

GLI

P08151

GLI1; GLI

E. coli

800-849 aa encoded by NM_005269 was inserted into PGEX-4T vector

Human

Not tested.