-
Product Name
Human GFER/ALR/HERV1/HPO (His tag) recombinant protein
- Documents
-
Description
GFER is a hepatotrophic growth factor and flavin-linked sulfhydryl oxidase which belongs to the Erv1/ALR family of proteins. GFER is widely expressed in various human tissues. They are two isoforms of this protein. Isoform 1 could regenerate the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen. Isoform 2 may act as an autocrine hepatotrophic growth factor promoting liver regeneration. GFER could also induce the expression of S-adenosylmethionine decarboxyl-ase and ornithine decarboxylases (ODC). S-adenosylmethionine decarboxyl-ase and ornithine decarboxylases play an important role in the synthesis of polyamines.
-
Protein name
growth factor, augmenter of liver regeneration(GFER)
-
Protein short names
ALR; HERV1; HPO
-
Uniprot ID
P55789
-
Source/Expression Host
E.coli
-
Expression Plasmid/cDNA
A DNA sequence encoding the Human GFER/ALR/HERV1/HPO Met1-Asp125 is expressed with a 6His tag at the N-terminus.
-
Protein Species
Human
-
Purity
>95% as determined by SDS-PAGE.
-
Validations
Human GFER/ALR/HERV1/HPO (His tag) recombinant protein
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"