Human Endoglin/CD105 (Fc Tag) recombinant protein

Cat.#: 504243

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Product Information

  • Product Name
    Human Endoglin/CD105 (Fc Tag) recombinant protein
  • Documents
  • Description
    Endoglin, also known as CD105, is a type I  homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD tripeptide which is a key recognition structure in cellular adhesion,,suggesting a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages. As an accessory receptor for the TGF-? superfamily ligands, endoglin binds TGF-?1 and TGF-?3 with high affinity not by itself but by associating with TGF-? type I I receptor (T?RII) and activates the downstream signal pathways. In addition, in human umbilical vein endothelial cells, ALK-1 is also a receptor kinase for endoglin threonine phosphorylation, and mutations in either of the two genes result in the autosomal-dominant vascular dysplasia, hereditary hemorrhagic telangiectasia (HHT). Endoglin has been regarded as a powerful biomarker of neovascularization, and is associated with several solid tumor types.
  • Protein name
    Endoglin (Osler-Rendu-Weber syndrome 1), isoform CRA_a
  • Uniprot ID
    Q96CG0
  • Gene Name
    ENG; hCG_18549
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the extracellular domain (Met 1-Gly 586) of human CD105 (NP_001108225.1) precursor was expressed with C-terminal fused human IgG1 Fc region.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human CD105/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 799 amino acids and has a predicted molecular mass of 87.5 kDa. As a result of glycosylation, rhCD105/Fc monomer migrates as an approximately 115-120 kDa protein in SDS-PAGE under reducing conditions.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Activity
    1. Measured by its ability to bind biotinylated Human TGFRB1 in a functional ELISA.
    2. Measured by its ability to bind biotinylated Human ALK1-Fc (Cat:501915) in functional Elisa.
  • Validations

    Human Endoglin / CD105 / ENG Protein (Fc Tag) SDS-PAGE

    Human Endoglin / CD105 / ENG Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"