Human EDAR/Ectodysplasin A Receptor (Fc Tag) recombinant protein

Human EDAR/Ectodysplasin A Receptor (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Tumor necrosis factor receptor superfamily member EDAR is a Single-pass type I membrane protein. Edar was expressed reiteratively in signaling centers regulating key steps in morphogenesis. activin signaling from mesenchyme induces the expression of the TNF receptor edar in the epithelial signaling centers, thus making them responsive to Wnt-induced ectodysplasin from the nearby ectoderm. This is the first demonstration of integration of the Wnt, activin, and TNF signaling pathways. Defects in EDAR are a cause of ectodermal dysplasia anhidrotic (EDA), also known ectodermal dysplasia hypohidrotic autosomal recessive (HED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDA is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands.

Tumor necrosis factor receptor superfamily member EDAR

EDAR; ED3; DL; EDA-A1R; HRM1; ED1R; EDA1R; ECTD10B; FLJ94390; EDA3; ED5; ECTD10A

Q9UNE0

EDAR; DL

Human Cells

A DNA sequence encoding the human EDAR (NP_071731.1) extracellular domain (Met 1-Ile 189) was fused with the Fc region of human IgG1 at the C-terminus.

Human

The recombinant human EDAR/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 404 amino acids and predicts a molecular mass of 44.6 kDa. As a result of glycosylation, the apparent molecular mass of rh EDAR/Fc monomer is approximately 52 kDa in SDS-PAGE under reducing conditions.

> 96 % as determined by SDS-PAGE