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Product Name
Human DNMT3A Recombinant protein (GST tag)
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Description
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. {PubMed:16357870}.
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Protein name
DNA
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Uniprot ID
Q9Y6K1
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Gene Name
DNMT3A
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human DNMT3A (XP_054196876.1) 1-280 aa was fused with the N-terminal GST tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human DNMT3A SDS-PAGE
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