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  • Human CXCL2/GRO2/GROB/MIP2A/SCYB2 recombinant protein

Human CXCL2/GRO2/GROB/MIP2A/SCYB2 recombinant protein

Cat.#: 518217

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Product Information

  • Product Name
    Human CXCL2/GRO2/GROB/MIP2A/SCYB2 recombinant protein
  • Documents
  • Description
    Chemokine (C-X-C Motif) Ligand 2 (CXCL2) is a small secreted cytokine which belongs to the CXC chemokine family. CXCL2 is 90% identical in amino acid sequence as a related chemokine, CXCL1. CXCL2/MIP2-alpha is secreted by monocytes and macrophages and is chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells. The gene for CXCL2 is located on human chromosome 4 in a cluster of other CXC chemokines. CXCL2 mobilizes cells by interacting with a cell surface chemokine receptor called CXCR2. CXCL2/MIP2-alpha has been known to regulate immune functions mainly by chemo-attracting neutrophils. It is produced by activated monocytes and neutrophils and expressed at sites of inflammation. CXCL2 is a hematoregulatory chemokine, which suppresses hematopoietic progenitor cell proliferation. CXCL2 can be induced by receptor activator of NF-kappaB ligand, the osteoclast (OC) differentiation factor, through JNK and NF-kappaB signaling pathways in OC precursor cells. CXCL2 in turn enhanced the proliferation of OC precursor cells of bone marrow-derived macrophages (BMMs) through the activation of ERK. Knockdown of CXCL2 inhibited both the proliferation of and the ERK activation in BMMs. During osteoclastogenesis CXCL2 stimulated the adhesion and the migration of BMMs. CXCL2 is a novel therapeutic target for inflammatory bone destructive diseases.
  • Protein name
    C-X-C motif chemokine ligand 2(CXCL2)
  • Protein short names
    GRO2; GROB; MIP2A; SCYB2
  • Uniprot ID
    P19875
  • Source/Expression Host
    E.coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Human CXCL2/GRO2/GROB/MIP2A/SCYB2 Thr39-Asn107 is expressed.
  • Protein Species
    Human
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Human CXCL2/GRO2/GROB/MIP2A/SCYB2 recombinant protein

    Human CXCL2/GRO2/GROB/MIP2A/SCYB2 recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"