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  • Human Bruton Tyrosine Kinase / BTK Kinase (His Tag) recombinant protein

Human Bruton Tyrosine Kinase / BTK Kinase (His Tag) recombinant protein

Cat.#: 501523

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Product Information

  • Product Name
    Human Bruton Tyrosine Kinase / BTK Kinase (His Tag) recombinant protein
  • Documents
  • Description
    Bruton's tyrosine kinase (or BTK) is a type of kinase protein expressed in B lymphocytes and T cells. BTK contains a PH domain which binds phosphatidylinositol(3,4,5)-trisphosphate (PIP3). After binding to PIP3, BTK is induced to phosphorylate phospholipase C, which in turn hydrolyzes PIP2 into two second messagers, IP3 and DAG, which then modulate the activity of downstream proteins during B-cell signaling. Btk is also found implicated in the primary immunodeficiency disease X-linked agammaglobulinemia(Bruton's agammaglobulinemia). BTK played a key role in B-cell maturation as well as mast cell activation through the high-affinity IgE receptor. Patients with X-linked agammaglobulinemia have normal pre-B cell populations in their bone marrow but these B-cells can not mature and enter the circulation.
  • Protein short names
    XLA; AGMX1; RP1-164F3.2; BPK; MGC126261; AT; RP23-91G19.5; MGC126262; PSCTK1; AI528679; BTK; ATK; XID; IMD1
  • Uniprot ID
    Q5JY90
  • Source/Expression Host
    Baculovirus-Insect Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human BTK (NP_000052.1) (Met 1-Ser 659) was expressed with a C-terminal polyhistidine tag.
  • Protein Species
    Human
  • Molecular weight
    The secreted recombinant human BTK consists of 670 amino acids and predicts a molecular mass of 77.8 KDa.
  • Purity
    > 85 % as determined by SDS-PAGE
  • Activity
    1. The specific activity was determined to be 115 nmol/min/mg using Poly(Glu,Tyr)4:1 peptide as substrate.
    2. Measured by its ability to bind human BLNK in a functional ELISA.
  • Validations

    Human Bruton Tyrosine Kinase / BTK Kinase Protein (His Tag) SDS-PAGE

    Human Bruton Tyrosine Kinase / BTK Kinase Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"