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Product Name
Human AEG-1 Recombinant protein (GST tag)
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Description
Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {PubMed:15927426, PubMed:16452207, PubMed:18316612, PubMed:19111877}.
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Protein name
Protein LYRIC
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Protein short names
AEG1; LYRIC
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Uniprot ID
Q86UE4
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Gene Name
MTDH; AEG1; LYRIC
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human MTDH (NP_848927.2) 233-582 aa was fused with the N-terminal GST tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human AEG-1 SDS-PAGE
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