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Product Name
Recombinant HRG protein (His tag)
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Description
Recombinant Human Histidine-rich Glycoprotein (HRG) Fragment (aa 19-245) is a high-purity protein designed for studying the Cystatin 1 domain. This fragment provides a focused tool to investigate HRG's roles in immune regulation, angiogenesis, and coagulation pathways, enabling precise domain-specific functional analysis.
Histidine-rich glycoprotein (HRG) is a multifunctional plasma glycoprotein that binds diverse ligands including heme, heparin, plasminogen, and metal ions. It functions as an adapter protein regulating immune complex clearance, pathogen removal, cell adhesion, angiogenesis, coagulation, and fibrinolysis. HRG mediates necrotic cell clearance via heparan sulfate-dependent phagocytosis, modulates VEGF signaling to inhibit endothelial cell motility, and normalizes tumor vasculature by polarizing macrophages. The protein is secreted and plays critical roles in maintaining vascular and immune homeostasis.
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Protein name
Histidine-rich glycoprotein
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Uniprot ID
P04196
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Gene Name
HRG
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 19-245 aa (P04196) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 27.82 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 31 kDa band.
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Purity
>89%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"