Recombinant HES1 protein (His tag)

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Recombinant Human HES-1 Protein Fragment (aa 38-185) is a high-purity, functional fragment encompassing the critical Orange domain (aa 110-143) of the Transcription factor HES-1. This product is an essential tool for researchers studying transcriptional repression, bHLH-mediated gene regulation, and DNA damage response pathways, offering targeted insights into domain-specific mechanisms.

HES-1 (Hairy and enhancer of split 1) is a Class B basic helix-loop-helix (bHLH) transcriptional repressor in humans that regulates genes requiring bHLH proteins for transcription. It binds with high affinity to N-box motifs (5'-CACNAG-3') and low affinity to E-box motifs (5'-CANNTG-3'), acting as a negative regulator in processes such as myogenesis by inhibiting MYOD1 and ASH1 functions. Additionally, HES-1 contributes to DNA damage response by stabilizing the FA core complex, promoting nuclear localization of its components, and facilitating FANCD2 monoubiquitination upon DNA cross-link damage. The protein is localized to the nucleus, underscoring its role in gene expression control and cellular stress responses.