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Product Name
Human Hemojuvelin / HFE2 (His Tag) recombinant protein
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Description
Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis.
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Protein name
Hemojuvelin
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Protein short names
HEMOCHROMATOSIS TYPE 2 PROTEIN; DL-M; 5230400G09RIK; JH; HFE2A; RGM DOMAIN FAMILY MEMBER C; HJV; AI789733; HEMOJUVELIN; RGMC; HEMOCHROMATOSIS TYPE 2 PROTEIN HOMOLOG; REPULSIVE GUIDANCE MOLECULE C; HAEMOJUVELIN; AI414844; MGC23953; 2310035L15RIK
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Uniprot ID
Q6ZVN8
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Gene Name
HFE2; HJV; RGMC
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mature form of human HFE2 isoform a (Q6ZVN8-1) (Met 1-Ser 399) was fused with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The secreted recombinant human HFE2 consists of 374 amino acids and predicts a molecular mass of 40 kDa. As a result of intracellular cleavage, the apparent molecular mass of the protein is approximately 20, 34 and 44 KDa in SDS-PAGE under reducing conditions, corresponding to the N-terminal, C-terminal portions and the full-length respectively.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human Hemojuvelin / HFE2 Protein (His Tag) SDS-PAGE
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