Recombinant HDAC8 protein (His tag)

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Recombinant Human Histone Deacetylase 8 (HDAC8) fragment (amino acids 1-377) is a high-purity, stable protein designed for structural and biochemical studies. This soluble fragment retains key functional domains, enabling researchers to investigate HDAC8's roles in epigenetic regulation, transcriptional control, and cell cycle progression.

Histone deacetylase 8 (HDAC8) is a crucial enzyme in epigenetic regulation, catalyzing the deacetylation of lysine residues on core histones H2A, H2B, H3, and H4. This activity facilitates transcriptional repression and influences cell cycle progression and developmental processes. HDAC8 also mediates the deacetylation of cohesin complex protein SMC3, regulating cohesin release from chromatin, and may contribute to smooth muscle cell contractility. Additionally, it functions as a protein decrotonylase, removing crotonyl modifications from histones. The enzyme localizes primarily to the nucleus and chromosomes but is excluded from nucleoli, and is found in the cytoplasm of smooth muscle cells. HDAC8 operates within multiprotein complexes to exert its diverse cellular functions.