Recombinant HDAC4 protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

This recombinant protein is a 434-amino acid fragment (residues 651-1084) of Human Histone Deacetylase 4 (HDAC4, EC 3.5.1.98), designed for structural and biochemical studies. It represents a stable, soluble unit ideal for investigating HDAC4's role in epigenetic regulation and cellular processes.

Histone deacetylase 4 (HDAC4) is a key enzyme responsible for deacetylating lysine residues on core histones (H2A, H2B, H3, H4), leading to epigenetic repression and playing critical roles in transcriptional regulation, cell cycle progression, and development. It functions within multiprotein complexes and is involved in muscle maturation through interactions with myocyte enhancer factors (MEF2A, MEF2C, MEF2D). HDAC4 also contributes to MTA1-mediated epigenetic regulation of ESR1 in breast cancer and deacetylates HSPA1A and HSPA1B to influence chaperone binding. Subcellularly, HDAC4 shuttles between the nucleus and cytoplasm, with nuclear accumulation during muscle differentiation and cytoplasmic retention mediated by phosphorylation and interactions with proteins like 14-3-3 chaperones and SIK3, highlighting its dynamic regulatory mechanisms in cellular signaling.