Recombinant HAX1 protein (His tag)

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Recombinant HCLS1-associated protein X-1 (HAX-1) fragment (residues 182-279) is a highly stable and soluble protein segment derived from human HAX1, optimized for structural and biochemical studies. This fragment retains key properties for investigating HAX-1's roles in actin cytoskeleton regulation, cell migration, and apoptosis inhibition, providing a valuable tool for life science research.

HAX-1 is a multifunctional human protein involved in critical cellular processes including actin cytoskeleton reorganization at the cell cortex through Arp2/3 complex recruitment, regulation of potassium channel KCNC3 inactivation kinetics, and promotion of GNA13-mediated cell migration. It participates in clathrin-mediated endocytosis and may facilitate internalization of ABC transporters. HAX-1 demonstrates anti-apoptotic activity through potential inhibition of CASP9 and CASP3, promotes cell survival, and may regulate intracellular calcium pools. The protein localizes to multiple cellular compartments including the mitochondrial matrix, endoplasmic reticulum, nuclear membrane, cytoplasmic vesicles, cell cortex, and P-bodies, with specific isoforms showing dynamic nucleocytoplasmic shuttling. This widespread subcellular distribution reflects its diverse functional roles in cellular signaling and homeostasis.