Recombinant GUC2C protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Recombinant Human Guanylyl Cyclase C (GC-C) Fragment (residues 24-430) is a high-purity protein designed for structural and biochemical studies. This 407-amino acid fragment represents a stable and soluble unit of GC-C, enabling research into its role in cyclic GMP synthesis and enterotoxin receptor function.

Guanylyl Cyclase C (GC-C), encoded by the GUCY2C gene, is a membrane-bound enzyme that catalyzes the synthesis of cyclic GMP (cGMP) from GTP. It functions as a receptor for E. coli heat-stable enterotoxin, which markedly stimulates cGMP accumulation in mammalian cells. GC-C is also activated by endogenous peptides guanylin and uroguanylin, implicating it in intestinal fluid homeostasis and signaling pathways. The full-length protein localizes to the cell membrane and endoplasmic reticulum as a single-pass type I membrane protein, with differentially glycosylated forms contributing to its subcellular distribution. This recombinant fragment provides a valuable tool for investigating GC-C's enzymatic activity and ligand interactions without membrane-associated complexities.