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Product Name
Recombinant GSTM5 protein (His tag)
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Description
Recombinant Human Glutathione S-transferase Mu 5 (GSTM5-5) Fragment (residues 1-218) is a high-purity protein designed for studying glutathione conjugation and detoxification pathways. This fragment fully encompasses the GST N-terminal and C-terminal domains, making it an ideal tool for investigating domain-specific functions in xenobiotic metabolism and cellular defense mechanisms.
Glutathione S-transferase Mu 5 (GSTM5) is a human cytoplasmic enzyme that catalyzes the conjugation of reduced glutathione to various exogenous and endogenous hydrophobic electrophiles, playing a crucial role in cellular detoxification and protection against oxidative stress. As a member of the GST class-mu family, it contributes to phase II metabolism by facilitating the elimination of toxic compounds and reactive intermediates. The enzyme's cytoplasmic localization enables its direct involvement in intracellular defense mechanisms against electrophilic challenges.
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Protein name
Glutathione S-transferase Mu 5
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Uniprot ID
P46439
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Gene Name
GSTM5
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-218 aa (P46439) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 27.33 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 29 kDa band.
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Purity
>85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"