Recombinant GSTM2 protein (His tag)

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This recombinant protein product features the human Glutathione S-transferase Mu 2 (GSTM2-2), a key enzyme involved in detoxification and bioactive lipid synthesis. The fragment spans amino acids 1-218, encompassing the complete GST N-terminal and C-terminal domains, making it an ideal tool for studying glutathione conjugation mechanisms and domain-specific functions in cellular defense pathways.

Glutathione S-transferase Mu 2 (GSTM2) is a cytoplasmic enzyme that catalyzes the conjugation of reduced glutathione to various hydrophobic electrophiles, facilitating the detoxification of exogenous and endogenous compounds. Notably, it participates in the biosynthesis of novel hepoxilin regioisomers, which are involved in inflammatory and regulatory processes. As a cytosolic protein, GSTM2 operates within the cell's primary metabolic compartment, playing a critical role in cellular protection against electrophilic stress and in the modulation of lipid-mediated signaling pathways.