Recombinant GSTA4 protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Recombinant Human Glutathione S-transferase A4 (GSTA4) Fragment (residues 1-222) is a high-purity protein designed for studying glutathione conjugation and detoxification pathways. This fragment fully encompasses the GST N-terminal and C-terminal domains, making it an ideal tool for investigating the enzyme's catalytic activity with substrates like 4-hydroxynonenal (4-HNE) in a controlled experimental setting.

Glutathione S-transferase A4 (GSTA4) is a cytoplasmic enzyme in humans that catalyzes the conjugation of reduced glutathione to a broad range of hydrophobic electrophiles, both exogenous and endogenous. It plays a critical role in cellular detoxification and oxidative stress response, with particularly high catalytic efficiency for reactive aldehydes such as 4-hydroxynonenal (4-HNE), a key product of lipid peroxidation linked to various pathological conditions. The enzyme's localization in the cytoplasm underscores its involvement in protecting cellular components from electrophilic damage, making it a significant target for research in toxicology, metabolism, and disease mechanisms.