Recombinant GST2 protein (His tag)

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Recombinant Glutathione S-transferase theta-2 (GSTT2) fragment (residues 2-244) from Homo sapiens, a 243-amino acid protein that includes the complete GST N-terminal and C-terminal domains. This fragment is engineered for studying glutathione conjugation and sulfatase activities in a purified, functional form, ideal for enzyme assays, binding studies, and mechanistic research.

Glutathione S-transferase theta-2 (GSTT2), encoded by the GSTT2 gene in humans, functions in the conjugation of reduced glutathione to diverse hydrophobic electrophiles, facilitating detoxification of exogenous and endogenous compounds. It also exhibits sulfatase activity, contributing to cellular metabolic processes. The protein is primarily localized in the cytoplasm and cytosol, with evidence of nuclear presence, indicating potential roles in cellular defense and signaling pathways. This recombinant fragment retains key functional domains, enabling focused investigation into its catalytic and regulatory mechanisms.