• GPQGIWGQK peptide

GPQGIWGQK peptide

Not For Human Use, Lab Use Only.

Cat.#: 319531

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Optional Service: TFA RemovalWhat's this?

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Product Information

  • Product Name
    GPQGIWGQK peptide
  • Documents
  • Sequence Shortening
    H-GPQGIWGQK-OH
  • Sequence
    H-Gly-Pro-Gln-Gly-Ile-Trp-Gly-Gln-Lys-OH
  • Length (aa)
    9
  • Peptide Purity (HPLC)
    95.43%
  • Molecular Formula
    C44H67N13O12
  • Molecular Weight
    970.08
  • Source
    Synthetic
  • Form
    Powder
  • Description
    GPQGIWGQK is a proteolytically cleavable peptide used in the synthesis of bioartificial hydrogel matrices for therapeutic vascularization. It is reacted with acrylate-PEG 3400 -NHS to synthesize MMP-degradable PEGDA macromer (A-PEG-GPQ-PEG-A). The A-PEG-GPQ-PEG-A hydrogel matrix, containing the GPQGIWGQK peptide, exhibits degradation-dependent VEGF release and supports cell adhesion activities. The hydrogel matrix with GPQGIWGQK peptide promotes subcutaneous vessel growth in rats, showing potential for vascularization in tissue engineering applications. The GPQGIWGQK peptide, when incorporated into the hydrogel matrix, allows for controlled release of VEGF, which is important for promoting angiogenesis and tissue regeneration. The bioartificial matrices containing GPQGIWGQK peptide have shown promise in promoting vascularization and could have potential applications in regenerative medicine and tissue engineering.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Phelps EA, Landázuri N, Thulé PM, Taylor WR, García AJ. Bioartificial matrices for therapeutic vascularization. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3323-8. doi: 10.1073/pnas.0905447107. Epub 2009 Dec 31. PMID: 20080569; PMCID: PMC2840448.
  • About TFA salt

    Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.

    TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.

    TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.

    In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"