Recombinant GPC5 protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Recombinant Human Glypican-5 Fragment (residues 1-348) is a high-purity protein designed for structural and biochemical studies. This soluble and stable fragment retains key functional characteristics of the full-length protein, which is a heparan sulfate-bearing proteoglycan involved in cell surface signaling, making it an ideal tool for investigating molecular interactions and mechanisms.

Glypican-5, encoded by the GPC5 gene, is a cell surface proteoglycan that carries heparan sulfate chains, playing a role in modulating cellular signaling pathways. It is anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) moiety and is localized to the extracellular side of the cell membrane. A cleaved form, known as secreted glypican-5, is also present in the extracellular space, suggesting roles in both membrane-bound and soluble contexts. This recombinant fragment (residues 1-348) was selected for its stability and solubility, enabling detailed analysis of glypican-5 function without the complexities of the full-length protein.

1-348