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Product Name
Recombinant GPC1 protein (His tag)
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Description
Recombinant Human Glypican-1 Fragment (aa 24-475) is a high-purity protein designed for structural and biochemical research. This soluble fragment retains key functional regions, making it ideal for studying heparan sulfate-mediated interactions, lipid raft associations, and roles in cellular processes such as myelination and protein conversion.
Glypican-1 (GPC1) is a cell surface proteoglycan in humans that carries heparan sulfate chains, enabling it to bind collagen alpha-4 (V) and support Schwann cell myelination. It facilitates the conversion of prion protein forms by anchoring them in lipid rafts and regulates skeletal muscle differentiation by sequestering FGF2 to inhibit FGF signaling. Located on the extracellular side of the cell membrane via a GPI-anchor, it also cycles through endosomes and associates with proteins like APP and CP in intracellular compartments, with cleaved forms secreted into the extracellular space. These functions highlight its importance in neural, muscular, and disease-related pathways.
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Protein name
Glypican-1 [Cleaved into: Secreted glypican-1]
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Uniprot ID
P35052
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Gene Name
GPC1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 24-475 aa (P35052) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 52.10 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 53 kDa band.
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Purity
>85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"