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Product Name
Recombinant GPAT4 protein (His tag)
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Description
This recombinant protein product features a stable and soluble fragment (residues 201-456) of human Glycerol-3-phosphate acyltransferase 4 (GPAT4), an enzyme critical for initiating glycerolipid synthesis. The fragment is optimized for structural and biochemical studies, offering researchers a reliable tool to investigate GPAT4's role in lipid metabolism and cellular protection.
Glycerol-3-phosphate acyltransferase 4 (GPAT4) catalyzes the first committed step in glycerolipid biosynthesis by converting glycerol-3-phosphate to lysophosphatidic acid (LPA), utilizing both saturated and unsaturated long-chain fatty acyl-CoAs as substrates. Beyond its fundamental role in lipid synthesis, GPAT4 has been shown to protect cells against lipotoxicity, highlighting its importance in maintaining cellular lipid homeostasis. The enzyme is localized to the endoplasmic reticulum membrane as a multi-pass membrane protein, where it performs its essential functions in lipid metabolic pathways.
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Protein name
Glycerol-3-phosphate acyltransferase 4
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Uniprot ID
Q86UL3
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Gene Name
GPAT4; AGPAT6; TSARG7
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 201-456 aa (Q86UL3) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 30.85 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 31 kDa band.
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Purity
>86%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"