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Product Name
Recombinant GNAT2 protein (His tag)
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Description
Recombinant Human Guanine nucleotide-binding protein G(t) subunit alpha-2 (GNAT2), encompassing amino acids 2-354. This fragment fully includes the critical G-alpha domains, providing researchers with a functional tool to investigate phototransduction signaling mechanisms in visual systems.
Guanine nucleotide-binding proteins (G proteins) serve as essential modulators and transducers in transmembrane signaling pathways. Transducin specifically acts as an amplifier and transducer in visual impulse signaling, facilitating the critical coupling between rhodopsin and cGMP-phosphodiesterase in phototransduction cascades. The protein demonstrates dynamic subcellular localization, primarily residing in photoreceptor outer segments during dark-adapted states and translocating to inner segments during light adaptation. This light-dependent translocation, regulated by UNC119, represents an important protective mechanism against photoreceptor damage, highlighting the protein's significance in visual physiology and photoprotection.
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Protein name
Guanine nucleotide-binding protein G
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Uniprot ID
P19087
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Gene Name
GNAT2; GNATC
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 2-354 aa (P19087) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 41.70 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 46 kDa band.
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Purity
>89%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"