Recombinant GNAQ protein (His tag)

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Recombinant Human GNAQ (G-alpha domain, residues 1-359) is a high-purity protein fragment ideal for investigating Gq-mediated signaling pathways. This product encompasses the complete G-alpha domain, enabling researchers to study GTP binding, hydrolysis, and downstream effector interactions in a controlled in vitro setting.

Guanine nucleotide-binding protein G(q) subunit alpha (GNAQ) functions as a critical transducer downstream of G protein-coupled receptors (GPCRs), cycling between active GTP-bound and inactive GDP-bound states to regulate signaling cascades. It primarily activates phospholipase C-beta (PLC-β), leading to the production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3), which are essential for cellular processes such as platelet activation, B-cell survival, and chemotaxis. GNAQ is localized at the cell membrane via lipid anchoring and has also been observed in the Golgi apparatus and nuclear membrane, where it colocalizes with adrenergic receptors in cardiac myocytes. Its role in FFAR4 signaling in response to long-chain fatty acids further underscores its importance in metabolic and immune regulation.