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Product Name
Recombinant GNA13 protein (His tag)
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Description
Recombinant Human Guanine nucleotide-binding protein subunit alpha-13 (G alpha-13) fragment (residues 1-377) is a high-purity protein designed for studying G-protein signaling pathways. This fragment fully encompasses the functional G-alpha domain, making it an ideal tool for investigating RhoA activation, cell migration, and metastasis mechanisms in cancer research and cell biology.
Guanine nucleotide-binding protein subunit alpha-13 (GNA13) functions as a modulator and transducer in transmembrane signaling systems. It activates RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF, and ARHGEF12/LARG), regulating transcription factor AP-1 and promoting tumor cell invasion and metastasis through the RhoA/ROCK signaling pathway. GNA13 also inhibits CDH1-mediated cell adhesion independently of Rho activation and transmits signals in lymphoid follicles that inhibit germinal center B cell growth and migration. The protein localizes to the cell membrane (via lipid anchor), melanosome, cytoplasm, and nucleus, with identified presence in melanosome fractions and germ cells during spermatogenesis.
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Protein name
Guanine nucleotide-binding protein subunit alpha-13
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Uniprot ID
Q14344
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Gene Name
GNA13
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-377 aa (Q14344) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 45.71 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 48 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"