Recombinant GMPR2 protein (His tag)

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Recombinant Human GMP Reductase 2 (GMPR2) Fragment (1-348) is a high-purity protein product designed for structural and biochemical studies. This fragment encompasses the full-length protein and retains the enzymatic activity essential for catalyzing the NADPH-dependent conversion of GMP to IMP, supporting research on nucleotide metabolism and cellular differentiation.

GMP Reductase 2 (GMPR2) is a critical enzyme in nucleotide metabolism, catalyzing the irreversible NADPH-dependent deamination of GMP to IMP. This reaction is vital for converting guanine-derived nucleotides to adenine nucleotides, thereby maintaining the intracellular balance of purine nucleotides. GMPR2 also plays a significant role in modulating cellular differentiation, as evidenced by studies linking its activity to developmental and regulatory processes. The provided fragment (residues 1-348) represents a stable and soluble unit of the protein, selected through computational predictions to facilitate reliable experimental outcomes in structural and functional assays.