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Product Name
Human Glutaminyl cyclase / QPCT (His Tag) recombinant protein
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Description
Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.
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Protein name
Glutaminyl-peptide cyclotransferase
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Protein short names
GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE (GLUTAMINYL CYCLASE); QPCT; QC; EC; GLUTAMINYL CYCLASE; GLUTAMYL CYCLASE; 5730422A13RIK; GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE; GLUTAMINYL-TRNA CYCLOTRANSFERASE; GCT; SQC
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Uniprot ID
Q16769
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Gene Name
QPCT
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human QPCT (Q16769-1) (Ala33-Leu361) was fused with a polyhistide tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human QPCT consists of 345 amino acids and has a calculated molecular mass of 39.7 kDa. The recombinant protein migrates as an approximately 38 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human Glutaminyl cyclase / QPCT Protein (His Tag) SDS-PAGE
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