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Product Name
Human Glucokinase recombinant protein
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Description
Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.
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Protein name
Glucokinase
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Protein short names
GCK; HK IV; HEXOKINASE TYPE IV; HEXOKINASE-DRP23-340E18.1; HLB62; FGQTL3; PANCREATIC ISOZYME; MODY2; LGLK; HKIV; GLUCOKINASE; HXKP; HK4; OTTMUSP00000006667; HHF3; GK; HEXOKINASE 4; HEXOKINASE D; HEXOKINASE-DFGQTL3; GLK; GLS006
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Uniprot ID
Q53Y25
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Gene Name
GCK
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human glucokinase isoform 1 (NP_000153.1) (Leu 2-Gln 465) was expressed, fused with two additional amino acids (Gly & Pro) at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human GCK isoform 1 consists of 466 amino acids and predicts a molecular mass of 52.2 kDa as estimated in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Activity
Kinase activity untested
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Validations
Human Glucokinase / GCK Protein SDS-PAGE
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