Ghrelin [1-27] peptide

Ghrelin [1-27] peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-GSSFLSPEHQRVQQRKESKKPPAKLQP-OH

H-Gly-Ser-Ser-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-OH

27

95.13%

C₁₃₅H₂₂₃N₄₃O₄₀

3088.46

Synthetic

Powder

Ghrelin [1-27] is a synthetic peptide derived from ghrelin, a 28-amino acid peptide that acts as an endogenous ligand for the growth hormone secretagogue receptor (GHS-R).
Ghrelin [1-27] lacks the C-terminal Arg 28 residue found in the full-length ghrelin peptide. It is one of the ghrelin-derived molecules that were isolated and characterized during the purification of human ghrelin from the stomach.
Synthetic Ghrelin [1-27] has been shown to induce increases in intracellular calcium levels in cells expressing GHS-R, similar to other ghrelin forms such as ghrelin, decanoyl ghrelin, and decanoyl ghrelin-(1-27).

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Hosoda H, Kojima M, Mizushima T, Shimizu S, Kangawa K. Structural divergence of human ghrelin. Identification of multiple ghrelin-derived molecules produced by post-translational processing. J Biol Chem. 2003;278(1):64-70.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.