Recombinant GDNF protein (His tag)

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This recombinant protein is a 96-amino acid fragment (residues 116-211) of human Glial cell line-derived neurotrophic factor (hGDNF), designed for structural and biochemical studies. It represents a stable, soluble unit of this key neurotrophic factor, which supports dopaminergic neuron survival and function, making it ideal for neuroscience and cell signaling research.

Glial cell line-derived neurotrophic factor (GDNF), encoded by the GDNF gene in Homo sapiens, is a secreted neurotrophic factor that plays a critical role in enhancing the survival and morphological differentiation of dopaminergic neurons, as well as increasing their high-affinity dopamine uptake. It functions by binding to its coreceptor GFRA1, which triggers autophosphorylation and activation of the RET receptor, facilitating neural development, including that of the neural crest. As a secreted protein, GDNF is released into the extracellular space, where it mediates its neuroprotective and developmental effects, underscoring its importance in neurological health and disease research.