Recombinant FZD7 protein (His tag)

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Recombinant Frizzled-7 (Fz-7) Fragment (47-162) is a high-quality, soluble protein derived from the human FZD7 gene. This 116-amino acid fragment is engineered for stability and solubility, making it an ideal tool for structural studies, biochemical assays, and investigating Wnt signaling pathways in a controlled experimental setting.

Frizzled-7 (FZD7) is a multi-pass transmembrane receptor in humans that plays a critical role as a receptor for Wnt proteins, primarily activating the canonical Wnt/β-catenin signaling pathway. This pathway regulates key cellular processes, including gene expression via disheveled proteins and GSK-3 kinase inhibition. Additionally, FZD7 is involved in non-canonical Wnt signaling through interactions with proteins like CCDC88C, leading to G-protein activation and cellular polarity modulation during tissue morphogenesis. It localizes to the cell membrane and endosomes, with membrane association influenced by phosphatidylinositol 4,5-bisphosphate (PIP2). Notably, FZD7 also serves as a receptor for microbial pathogens, such as Clostridium difficile toxin TcdB in colonic epithelium, highlighting its broader physiological and pathological relevance.