FOXO4 D-Retro-Inverso(DRI) peptide (TFA removed)
Batch to batch variation of the purity
Three letter code
Peptide Purity (HPLC)
Note: the Net Peptide Content(NPC) of current batch is 69.92%. Click to view moreFOXO4 D-Retro-Inverso peptide, also known as FOXO4 DRI peptide was first reported in 'Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging' by Baar et al. FOXO4 DRI peptide comprising the amino acid sequence: LTLRKEPASEIAQSILEAYSQNGWANRRSGGKRP, wherein the amino acids in said amino acid sequence are D-amino acid residues. FOXO4 D-Retro-Inverso peptide selectively induces apoptosis of senescent cells reverses effects of chemotoxicity and aging in mice.
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
- Baar, Marjolein P. et al. Targeted Apoptosis Of Senescent Cells Restores Tissue Homeostasis In Response To Chemotoxicity And Aging. Cell 169.1 (2017): 132-147.e16. Web. 25 Mar. 2017.
About TFA salt
Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.
TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.
TFA Removal Service is recommended for:
- Peptides that will be used in cellular assays
- Peptides that will be used as APIs or in manufactured products
- For hydrophilic peptides containing numerous basic residues
- Analysed Sequence:H-(dL)(dT)(dL)(dR)(dK)(dE)(dP)(dA)(dS)(dE)(dI)(dA)(dQ)(dS)(dI)(dL)(dE)(dA)(dY)(dS)(dQ)(dN)(dG)(dW)(dA)(dN)(dR)(dR)(dS)(dG)(dG)(dK)(dR)(dP)(dP)(dP)(dR)(dR)(dR)(dQ)(dR)(dR)(dK)(dK)(dR)(dG)-OH
- Chemical Formula:C228H388N86O64
- Sequence length:46
- Extinction coefficient:0 M-1cm-1
- Mw average:5358.03
- Theoretical pI:12.41
- Data Source:Peptide Property Calculator
GRAVY = grand average of hydropathy
X: Hydrophobic uncharged residues, like F I L M V W A and P
X: Basic residues, like R K H
X: Acidic residues, like D E
X: Polar uncharged residues, like G S T C N Q and Y
Related Products / Services
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