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Product Name
Recombinant FN3K protein (His tag)
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Description
Recombinant Human Fructosamine-3-kinase (FN3K) Fragment (1-309) - A highly purified, stable protein fragment ideal for studying protein deglycation mechanisms and oxidative stress response pathways. This soluble fragment maintains key functional domains for structural and biochemical investigations.
Fructosamine-3-kinase (FN3K) is a crucial enzyme involved in protein deglycation through phosphorylation of fructoselysine residues on glycated proteins, generating unstable fructoselysine-3 phosphate adducts that decompose under physiological conditions. This enzyme plays a vital role in intracellular deglycation processes, particularly in erythrocytes, and contributes to the cellular response to oxidative stress by mediating deglycation of NFE2L2/NRF2, whose function is impaired by glycation. FN3K also exhibits activity toward psicosamines and ribulosamines, highlighting its broad substrate specificity in cellular detoxification pathways.
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Protein name
Fructosamine-3-kinase
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Uniprot ID
Q9H479
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Gene Name
FN3K
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-309 aa (Q9H479) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 36.83 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 37 kDa band.
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Purity
>87%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"