FMRFamide-like neuropeptide TPGQDFMRF-amide

FMRFamide-like neuropeptide TPGQDFMRF-amide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

TPGQDFMRF

H-Thr-Pro-Gly-Gln-Asp-Phe-Met-Arg-Phe-OH

9

95%

C₄₉H₇₁N₁₃O₁₄S

1097.50

Synthetic

Powder

The source of FMRFamide-like neuropeptide TPGQDFMRF-amide is Delia radicum. FMRFamide-like neuropeptide TPGQDFMRF-amide belongs to FMRFamide related peptide. FMRFamide-like neuropeptide TPGQDFMRF-amide is expressed in In larvae, expressed in the CNS and thoracic perisymapthetic organs (tPSO) but not in the ring gland or abdominal perisymapthetic organs (aPSO) (at protein level). In adults, expressed in brain and thoracic-abdominal ganglion but not in corpora cardiaca and corpora allata (at protein level). The peptide has the modification: 9 Phe amide

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides

• Audsley N., Matthews H.J., Down R.E., Weaver R.J.; Neuropeptides associated with the central nervous system of the cabbage root fly, Delia radicum (L).; Peptides 32:434-440(2011).

Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.

TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.

TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.

In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.