Recombinant FKBP3 protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Recombinant Human Peptidyl-prolyl cis-trans isomerase FKBP3 (PPIase FKBP3) fragment (amino acids 110-224) is a high-purity protein designed for studying the FKBP-type PPIase domain. This fragment fully encompasses the functional domain (residues 128-224), making it an ideal tool for investigating isomerase activity and immunophilin-related mechanisms in a targeted manner.

Peptidyl-prolyl cis-trans isomerase FKBP3 is a member of the FK506-binding protein (FKBP) family, which functions as receptors for immunosuppressants like FK506 and rapamycin. These proteins play critical roles in inhibiting T-cell proliferation by disrupting distinct cytoplasmic signaling pathways. As a PPIase, FKBP3 accelerates protein folding by catalyzing the cis-trans isomerization of proline imidic peptide bonds. The full-length protein is localized to the nucleus, indicating its potential involvement in nuclear processes. The recombinant fragment provided focuses specifically on the FKBP-type PPIase domain, enabling precise research into its isomerase functions and interactions without interference from other protein regions.