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Product Name
Human FGFBP3 (His Tag) recombinant protein
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Description
FGFBP3 is a member of the fibroblast growth factor-binding protein family. Members of this family binds and activates FGF-1 and FGF-2, thereby contributing to tumor angiogenesis. Fibroblast growth factors (FGFs) are important regulators of cell migration, proliferation and differentiation, e.g., during embryogenesis and wound healing, and under several pathological conditions including tumor growth and tumor angiogenesis. Expression of FGF-BP increases after injury to murine and human skin, in particular in keratinocytes. This upregulation is most likely achieved by major keratinocyte mitogens present at the wound site. FGFBP3 is a positive regulator of fibroblast growth factor receptor signaling pathway and vascular permeability. It interacts with 2,3,7,8-tetrachlorodibenzodioxine, benzopyrene and valproic acid. FGFBP3 also exhibits fibroblast growth factor binding (orthology) and heparin binding (orthology).
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Protein name
Fibroblast growth factor-binding protein 3
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Protein short names
2610306H15RIK; C10ORF13; PSEC0101; FGF-BINDING PROTEIN 3; FGFBP-3; FIBROBLAST GROWTH FACTOR-BINDING PROTEIN 3; FGF-BP3; MGC39320
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Uniprot ID
Q8TAT2
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Gene Name
FGFBP3; C10orf13; PSEC0101
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human FGFBP3 (Met 1-Gly 258) (Q8TAT2) was expressed, with a C-terminal polyhistidine tag.
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Protein Species
Human
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Molecular weight
The secreted recombinant human FGFBP3 consists of 243 amino acids and predicts a molecular mass of 26.4 KDa. The apparent molecular mass of the protein is approximately 33 Kda in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
> 87 % as determined by SDS-PAGE
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Validations
Human FGFBP3 Protein (His Tag) SDS-PAGE
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