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Product Name
Recombinant FGR protein (His tag)
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Description
Recombinant Human FGR Kinase Fragment (aa 79-529) – a high-purity protein tool designed for studying the specific functions of the SH2 and Protein kinase domains in signal transduction, immune regulation, and cytoskeletal dynamics.
Tyrosine-protein kinase Fgr (FGR) is a non-receptor tyrosine kinase that plays a critical role in immune cell signaling, including neutrophil, monocyte, macrophage, and mast cell functions. It transmits signals from cell surface receptors and regulates processes such as phagocytosis, cell adhesion, migration, cytoskeleton remodeling, and mast cell degranulation. Fgr acts downstream of immunoglobulin Fc receptors and integrins, modulating SYK activity, RAC1 activation, and phosphorylation of targets like PLD2, FASLG, and ABL1. It localizes to the cell membrane (particularly lipid rafts), membrane ruffles, the cytosol, cytoskeleton, and mitochondrial compartments. This recombinant fragment (aa 79-529) encompasses the SH2 and Protein kinase domains, enabling focused investigation of their roles in Fgr-mediated signaling pathways.
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Protein name
Tyrosine-protein kinase Fgr
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Uniprot ID
P09769
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Gene Name
FGR; SRC2
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 79-529 aa (P09769) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 53.00 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 55 kDa band.
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Purity
>89%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"