Recombinant FGFR3 protein (His tag)

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Recombinant Human FGFR3 (Fibroblast Growth Factor Receptor 3) Fragment (aa 47-375) is a high-purity protein designed for investigating the structural and functional roles of the Ig-like C2-type 2 and 3 domains. This fragment serves as an essential tool for studying FGFR3-mediated signaling pathways, receptor-ligand interactions, and its implications in skeletal development and cellular regulation.

Fibroblast Growth Factor Receptor 3 (FGFR3) is a tyrosine kinase receptor critical for regulating cell proliferation, differentiation, and apoptosis, with a key role in chondrocyte function and skeletal development. It activates multiple signaling cascades, including RAS/MAPK and AKT pathways, through phosphorylation of effectors like PLCG1 and FRS2. FGFR3 is primarily localized to the cell membrane as a single-pass type I protein, though isoforms vary in subcellular distribution, with isoform 1 internalizing upon activation and isoform 3 being secreted. Mutations in FGFR3 can lead to constitutive signaling, contributing to developmental disorders and cancer, underscoring its importance in biomedical research.