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Product Name
Recombinant FCMR protein (His tag)
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Description
Recombinant Human Immunoglobulin mu Fc Receptor (IgM FcR) Fragment (aa 17-126) – a high-purity protein fragment encompassing the essential Ig-like domain, designed for investigating IgM binding, immune regulation, and signaling pathways in B cell development and mucosal immunity.
The full-length Immunoglobulin mu Fc receptor (IgM FcR), encoded by the FCMR gene, is a high-affinity Fc receptor for both secreted and membrane-bound immunoglobulin M (IgM). It plays a critical role in IgM transport and homeostasis, facilitating exocytosis and endocytosis of IgM complexes in lymphoid cells and mediating retrotranscytosis of antigen-IgM complexes across mucosal epithelium. This receptor triggers costimulatory signaling, supports B cell development, and regulates primary immune responses to infections by engaging non-canonical NF-kappa-B, MAP kinases, and calcium signaling pathways. It is primarily localized to the cell membrane, with dynamic recycling between cytoplasmic pools and the plasma membrane, and is
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Protein name
Immunoglobulin mu Fc receptor
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Uniprot ID
O60667
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Gene Name
FCMR; FAIM3; TOSO
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 17-126 aa (O60667) were fused with N-terminal 6His tag.
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Sequence
MNHKVHHHHH HGGSLRILPE VKVEGELGGS VTIKCPLPEM HVRIYLCREM AGSGTCGTVV STTNFIKAEY KGRVTLKQYP RKNLFLVEVT QLTESDSGVY ACGAGMNTDR GKTQKVTLNV HSEY
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 13.77 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 14 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Validations
Recombinant FCMR protein (His tag) SDS-PAGE
M: Marker; Lane 1: FCMR; Lane 2: BSA
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"