Recombinant FCG3B protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Introducing the recombinant human Fc-gamma RIII-beta (CD16b) fragment (amino acids 17-200), a meticulously engineered protein that encompasses the essential Ig-like C2-type domains. This high-purity fragment serves as an invaluable tool for researchers investigating IgG Fc receptor interactions, immune complex trapping mechanisms, and neutrophil biology, providing targeted insights into this low-affinity immunoglobulin gamma Fc region receptor.

Fc-gamma RIII-beta (CD16b) is a glycosylphosphatidylinositol (GPI)-anchored membrane protein that functions as a low-affinity receptor for the Fc region of immunoglobulins gamma. Unlike its counterpart Fc-gamma RIII-A, this receptor binds both complexed/aggregated and monomeric IgG but does not mediate antibody-dependent cytotoxicity or phagocytosis. Current research indicates it primarily serves as a decoy receptor, trapping immune complexes in peripheral circulation without activating neutrophils. The protein is expressed on cell membranes via GPI-anchoring and can be secreted following proteolytic cleavage. Its specific role in immune regulation makes it a critical component in understanding autoimmune disorders and inflammatory responses.

17-200