Recombinant EYA2 protein (His tag)

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Recombinant Human Protein Phosphatase EYA2 (EC 3.1.3.48) Fragment (aa 266-538) is a high-purity, stable protein fragment designed for structural and biochemical studies. This fragment, derived from the Eyes Absent Homolog 2 protein, retains key functional characteristics and offers excellent solubility, making it ideal for investigating phosphatase activity and transcriptional coactivation mechanisms in research applications.

Protein Phosphatase EYA2 (Eyes Absent Homolog 2) is a dual-function enzyme that serves as both a protein phosphatase and a transcriptional coactivator for SIX family proteins, including SIX1, SIX2, SIX4, and SIX5. It plays a critical role in DNA repair by dephosphorylating Tyr-142 of histone H2AX (H2AXY142ph), which helps recruit DNA repair complexes containing MDC1 and distinguishes between apoptotic and repair responses to genotoxic stress. Additionally, EYA2 is essential for hypaxial muscle development, functioning redundantly with EYA1 in conjunction with SIX1 and DACH2. The protein localizes to both the cytoplasm and nucleus; it is retained in the cytoplasm through interaction with GNAZ and GNAI2, and translocates to the nucleus upon binding to SIX1, SIX2, SIX4, or SIX5, highlighting its regulatory importance in organogenesis and cellular stress responses.