Recombinant EXO1 protein (His tag)

• DataSheet
• COA (Batch NP456560)
• Material Safety Data Sheets (MSDS)

Recombinant Human Exonuclease 1 (hExo1) fragment (amino acids 1-377) - a highly purified, stable protein unit ideal for DNA repair mechanism studies, structural analysis, and enzymatic characterization. This carefully selected fragment maintains key functional properties while offering superior solubility for experimental applications.

Human Exonuclease 1 (EXO1) is a crucial 5'→3' double-stranded DNA exonuclease that plays essential roles in DNA mismatch repair (MMR), where it excises mismatch-containing DNA tracts directed by strand breaks. The enzyme also exhibits endonuclease activity against 5'-overhanging flap structures and is required for somatic hypermutation and class switch recombination of immunoglobulin genes. EXO1 is nuclear-localized, colocalizing with PCNA to discrete nuclear foci during S-phase, and is indispensable for both male and female meiosis. The full-length protein's multifaceted functions in DNA repair and recombination make it a critical target for understanding genomic stab

MGIQGLLQFI KEASEPIHVR KYKGQVVAVD TYCWLHKGAI ACAEKLAKGE PTDRYVGFCM KFVNMLLSHG IKPILVFDGC
TLPSKKEVER SRRERRQANL LKGKQLLREG KVSEARECFT RSINITHAMA HKVIKAARSQ GVDCLVAPYE ADAQLAYLNK
AGIVQAIITE DSDLLAFGCK KVILKMDQFG NGLEIDQARL GMCRQLGDVF TEEKFRYMCI LSGCDYLSSL RGIGLAKACK
VLRLANNPDI VKVIKKIGHY LKMNITVPED YINGFIRANN TFLYQLVFDP IKRKLIPLNA YEDDVDPETL SYAGQYVDDS
IALQIALGNK DINTFEQIDD YNPDTAMPAH SRSHSWDDKT CQKSANVSSI WHRNYSPLEH HHHHH