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Product Name
Recombinant EXO1 protein (His tag)
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Description
Recombinant Human Exonuclease 1 (hExo1) fragment (amino acids 1-377) - a highly purified, stable protein unit ideal for DNA repair mechanism studies, structural analysis, and enzymatic characterization. This carefully selected fragment maintains key functional properties while offering superior solubility for experimental applications.
Human Exonuclease 1 (EXO1) is a crucial 5'→3' double-stranded DNA exonuclease that plays essential roles in DNA mismatch repair (MMR), where it excises mismatch-containing DNA tracts directed by strand breaks. The enzyme also exhibits endonuclease activity against 5'-overhanging flap structures and is required for somatic hypermutation and class switch recombination of immunoglobulin genes. EXO1 is nuclear-localized, colocalizing with PCNA to discrete nuclear foci during S-phase, and is indispensable for both male and female meiosis. The full-length protein's multifaceted functions in DNA repair and recombination make it a critical target for understanding genomic stability mechanisms.
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Protein name
Exonuclease 1
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Uniprot ID
Q9UQ84
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Gene Name
EXO1; EXOI; HEX1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-377 aa (Q9UQ84) were fused with 6His tag.
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Sequence
1-377
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 44.08 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 44 kDa band.
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Purity
>86%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"