ESRRB antibody

ESRRB antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

ESRRB Rabbit Polyclonal antibody. Positive WB detected in PC-13 cells, A549 cells. Positive IP detected in A549 cells. Observed molecular weight by Western-blot: 45-49 kDa

ELISA, WB, IP

Human,Mouse,Rat; other species not tested.

DFNB35 antibody; ERR2 antibody; ERRb antibody; ERRbeta antibody; ERRbeta 2 antibody; ESRL2 antibody; ESRRB antibody; ESRRB protein antibody; estrogen related receptor beta antibody; NR3B2 antibody

Rabbit IgG

This antibody was obtained by immunization of ESRRB recombinant protein (Accession Number: XM_017021086). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Estrogen related receptor beta (ESRRB), a NR3 Steroid Receptor, has been shown to affect early placental development. Also it can act as a repressor of transcriptional activity mediated by the glucocorticoid receptor (GR). It binds as a monomer to the extended half-site TNAAGTGCA and as a homodimer to the estrogen response element (ERE), palindromic thyroid hormone response element (TRE(pal)), and SF-1 response element, but not to the glucocorticoid response element (GRE). Estrogen related receptor beta mutations lead to abnormal development of the chorion and defective diploid trophoblast proliferation, and are lethal during midgestation. Expression has been documented in mice in the extra embryonic ectoderm that gives rise to the chorion. ESTs have been isolated from normal human eye, lung, and testis libraries. The ligand for the receptor is PPARgamma coactivator 1 (PGC-1) beta.

• You KT, Park J, Kim VN. Role of the small subunit processome in the maintenance of pluripotent stem cells. Genes & development. 29(19):2004-9. 2015.