Recombinant EPHA8 protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Recombinant Human EPHA8 Protein Kinase Domain (residues 627-902) is a high-purity fragment of the Ephrin type-A receptor 8, encompassing the complete protein kinase domain. This product is engineered to support studies of kinase activity, signaling mechanisms, and domain-specific interactions, providing a focused tool for researchers investigating receptor tyrosine kinase function in neural development and cell adhesion.

Ephrin type-A receptor 8 (EPHA8) is a receptor tyrosine kinase that promiscuously binds GPI-anchored ephrin-A ligands, facilitating bidirectional signaling between neighboring cells. It plays critical roles in nervous system development, including axon guidance, neurite outgrowth, and integrin-mediated cell adhesion and migration on fibronectin substrates. Upon ligand binding, EPHA8 activates downstream effectors such as FYN and MAP kinases. The full-length protein is localized to the cell membrane, cell projections, and early endosomes, undergoing clathrin-mediated endocytosis after EFNA5 interaction. This recombinant fragment specifically targets the functional kinase domain, enabling detailed investigation of its catalytic and regulatory properties.